Metabolic syndrome and nephrolithiasis risk: should the medical management of nephrolithiasis include the treatment of metabolic syndrome?
Rev Urol ; The role of Randall''s plaques in the pathogenesis of calcium stones. J Urol ; Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int ; Renal crystal deposits and histopathology in patients with cystine stones.
Calyceal microlithiasis in children: report on cases. Pediatr Nephrol ; Diagnosis and metaphylaxis of stone disease.
World J Urol ; Results of 5, stone analyses: a contribution to epidemiology of urinary stone disease. Scand J Urol Nephrol ; En: V. The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?. Nefrologia May Simple test to evaluate the risk of urinary calcium stone formation. Clin Chim Acta. Moore ES. Hypercalciuria in children. Contrib Nephrol ; The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria.
Bone mineral density in pediatric patients with idiopathic hypercalciuria. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria.
J Clin Endocrinol Metab ; Weisinger JR. New insights into the pathogenesis of idiopathic hypercalciuria: the role of bone. Kidney Int. Differences in renal handling of sodium after hyposaline loading between children and adults with idiopathic hypercalciuria. En: Jungers P, Daudon M, editores. Renal stone disease. Crystallization process, pathophysiology, metabolic disorders and prevention. Paris: Elsevier; Peripheral blood monocyte vitamin D receptor levels are elevated in patients with idiopathic hypercalciuria.
Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature ; Uricosuric action of losartan via the inhibition of urate transporter 1 URAT 1 in hypertensive patients.
Am J Hypertens Oct;21 10 Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. The primary hyperoxalurias.
Pediatr Transplant. Two-step transplantation for primary hyperoxaluria: a winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases.
Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease. BMJ Case Rep ; Novas, J. Rodriguez, M. Ruibal, A. Knoll, A. Schubert, D. Fahlenkamp, D. Leusmann, G. Wendt-Nordahl, G. Urolithiasis through the ages: Data on more than , urinary stone analyses.
J Urol. Krambeck, J. Lieske, X. Li, E. Bergstralh, L. Melton, A. Effect of age on the clinical presentation of incident symptomatic urolithiasis in the general population. Reyes, M. Almaguer, T. History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol. Park, Y. Ha, Y. Kim, S. Yun, S. Lee, W. Comparison of metabolic risk factors in urolithiasis patients according to family history. Korean J Urol. Curhan, W. Willett, E. Rimm, M.
J Am Soc Nephrol. Eur Assoc Urol. Colorado, L. Ginecol Obs Mex. Naghii, M. Determinant role of gonadal sex hormones in the pathogenesis of urolithiasis in a male subject—a document for male predominancy case study. Endocr Regul. Maalouf, A. Sato, B. Welch, B. Howard, B. Cochrane, K. Sakhaee, et al. Postmenopausal hormone use and the risk of nephrolithiasis. Arch Intern Med. Davarci, M. Helvaci, M. What is the relationship between type 2 diabetes mellitus and urolithiasis?. Bratisl Lek List, , pp.
Daudon, O. Traxer, P. Conort, B. Lacour, P. Type 2 diabetes increases the risk for uric acid stones. Masterson, J. Woo, D. Chang, T. Chi, J. Stoller, et al. Dyslipidemia is associated with an increased risk of nephrolithiasis. Kang, S. Seo, W. Kim, Y-J. Kim, S-J. Yun, S-C. Lee, et al. Hypertriglyceridemia is associated with increased risk for stone recurrence in patients with urolithiasis.
Tsujihata, C. Momohara, I. Yoshioka, A. Tsujimura, N. Nonomura, A. Atorvastatin inhibits renal crystal retention in a rat stone forming model. Sur, J. Masterson, K. Palazzi, J. Auge, D. Chang, et al. Impact of statins on nephrolithiasis in hyperlipidemic patients: A year review of an equal access health care system.
Clin Nephrol. Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: Evidence from clinical and experimental investigations. Revista Aula de la Farmacia. Pais, A. Payton, C. Urol Clin North Am. Semins, B. Nephron ; 81 Suppl 1 Family history and risk of kidney stones. J Am Soc Nephrol ; Pri D, Friedlander G. Genetic causes of renal lithiasis. Hyperoxaluria in kidney stone formers treated with modern bariatric surgery.
J Urol ; Mahuang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis ; Snchez A. Dieta y urolitiasis. Rev Arg Endocrinol Metab ; Kramer HM, Curhan G. The association. Body size and risk of kidney stones. Obesity, weight gain, and the risk of kidney stones. JAMA ; Diabetes mellitus and the risk of nephrolithiasis. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium cannel gene.
J Bone Miner Res ; Peripheral blood monocyte vitamin D receptor levels are elevated in patients with idiopathic hypercalciuria. J Clin Endocrinol Metab ; El receptor-sensor de calcio y patologas asociadas. Proximal tubular defects in idiopathic hypercalciuria: Resistance to phosphate administration. Levi M, Bruesegem S. Renal phosphatetransporter regulatory proteins and nephrolithiasis. N Engl J Med ; Fibroblast growth factor 23 is increased in calcium nephrolithiasis with hypophosphatemia and renal phosphate leak.
Regulation of the epithelial calcium channel TRPV5 by extracellular factors. Bushinsky DA. Calcium nephrolithiasis. Renal phosphate leak in patients with idiopathic hypercalciuria and. Urol Res ; Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis. Potencia diagnstica de los tests de sobresaturacin urinaria en litisicos oxaloclcicos resumen.
P Smith LH. Diet and hyperoxaluria in the syndrome of idiopathic calcium oxalate urolithiasis. Niaudet P, Rose BD. Primary hyperoxaluria. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [ 13 C2]oxalate absorption test.
Ascorbic acid overdosing: A risk factor for calcium oxalate nephrolithiasis. Williams HE. Oxalic acid and the hyperoxaluric syndromes.
Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones. Erythrocyte transmembrane flux and renal clearance of oxalate in idiopathic calcium nephrolithiasis. Simpson DP. Citrate excretion: A window on renal metabolism. Am J Physiol ; F Hamm L. Renal handling of citrate. Pak CYC. Citrate and renal calculi. Growth of calcium oxalate crystals. Invest Urol ; Successful treatment. Arch Intern Med ; Raising urinary citrate lowers calcium oxalate and calcium phosphate crystal formation in whole urine.
Urol Int ; Inhibition by citrate of spontaneous precipitation of calcium oxalate, in vitro. Excesive crystal agglomeration with low citrate excretion in recurrent stone-formers. Lancet ; Kok DJ. Modulation of calcium oxalate monohydrate crystallization kinetics in vitro. Crystal agglomeration is a major element in calcium oxalate urinary stone formation. Citrate transport in rabbit nephron.
Wright EM. Transport of carboxylic acids by renal membrane vesicles. Ann Rev Physiol ; Adenosine triphosphate citrate lyase mediates hypocitraturia in rats. J Clin Invest ; Chronic potassium depletion stimulates rat renal brush-border membrane Na-citrate cotransporter.
Alkali absorption and citrate excretion in calcium nephrolithiasis. Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list. Nephrol Dial Transplant ; Escrezione urinaria de citrato e consumo alimentari di NaCl nella nefrolitiasi calcica recidivante.
Recurrent calcium nephrolithiasis associated with primary aldosteronism. Am J Kidney Dis ; e Biochemical and stone-risk profiles with topiramate treatment. Topiramate induced nephrolithiasis. J Endourol ; Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Associations between renal sodium-citrate cotransporter hNaDC. Int J Urol ; Urine risk factors in nephrolithiasis patients with and without bowel disease.
Type 2 diabetes increases the risk for uric acid stones. Metabolic risk factors and the impact of medical therapy on the management of nephrolithiasis in obese patients. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Recurrent uric acid stones. Q J Med ; Insulin stimulates ammoniagenesis in canine renal proximal tubular segments. Association of urinary pH with body weight in nephrolithiasis. Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis.
Low urine pH: a. Clin J Am Soc Nephrol ; Lesh Nyham syndrome. University of Washington; Seattle, Sep 25 [updated Jun 10]. Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation. Natural urinary macromolecular inhibitors: attenuation of inhibitory activity by urate salts. Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Nature ; Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. Uric acid-related nephrolithiasis. Urol Clin North Am ; Hyperuricemic syndromes in cancer patients. Contrib Nephrol ; Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. Broer S, Wagner CA.
Structure-function relationships of heterodimeric amino acid transporters. Cell Biochem Biophys ; Mol Membr Biol ; The structural and functional units of heteromeric amino acid transporters. J Biol Chem ; Wollaston WH. On cystic oxide: a new species of urinary calculus. Philos Trans R Soc Lond ; Toel F.
Beobachtungen uber Cystinebildung. Ann Chem Pharm ; Milliner D, Murphy M. Urolithiasis in pediatric patients. Mayo Clin Proc ; Cystinuria: biochemical evidence for three genetically distinct diseases. Management of cystinuria. Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine. Nat Genet ; New insights into cystinuria: 40 new mutations, genotype phenotype correlation, and digenic inheritance causing partial phenotype.
J Med Genet ; Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein.
Cystinuria subtype and the risk of nephrolithiasis. Renal crystal deposits and histopathology in patients with cystine stones. Cystine crystal volume determination: a useful tool in the management of cystinuric patients. The impact of cystinuria on renal function. Litiasis renal. Rosario; Corpus, Ureteral stones clinical guidelines panel summary report on the management of ureteral calculi.
Teichman J. Acute renal colic from ureteral calculus. An assessment of the clinical efficacy of intranasal desmopressin spray in the treatment of renal colic. BJU Int ; Local active warming: an effective treatment for pain, anxiety and nausea caused by renal colic. Intensive management of ureteral calculi. Urology ; Efficacy of alpha-blockers for the treatment of ureteral stones. Hess B. Ther Umsch ; Actuacin y experiencia en el estudio metablico y en tratamiento mdico-quirrgico.
Urolitiasis clcica. Estudio de 90 pacientes. Medicina B Aires ; Should patients with single stone occurrence undergo diagnostic evaluation? Ambulatory evaluation of nephrolithiasis: an update of a protocol.
Paris; Health Publications, Comparison of patients with idiopathic calcium phosphate and calcium oxalate stones. Medicine Baltimore ; Equil2: a basic computer program for the calculation of urinary saturation. The Brazilian Multicentric Study of Nephrolithiasis. Dallas; Millet The Printer, Metabolic risk factors in children with kidney stone disease.
Pediatr Nephrol ; Clinical and metabolic features of urolithiasis and microlithiasis in children. Human vitamin and mineral requirements; Rome, Lemann J. Composition of the diet and calcium kidney stones Editorial. Recurrent hypercalciuric nephrolithiasis does diet help? Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of followup.
Total antioxidant and ascorbic acid content of fresh fruits and vegetables: implications for dietary planning and food preservation. Br J Nutr ; Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria.
Diet, fluid, or supplements for secondary prevention of nephrolithiasis: a systematic review and meta-analysis of randomized trials. Eur Urol ; Diet to reduce mild hyperoxaluria in patients with idiopathic calcium oxalate stone formation: a pilot study.
Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis : a 5-year randomized propective study. Update on the medical management of stone disease. Curr Opin Urol ; Effect of two sports drinks on urinary lithogenicity. The effect of fruits and vegetables on urinary stone risk factors. The effects of dietary excesses in animal protein and in sodium on the composition and the crystallization kinetics of calcium oxalate monohydrate in urines of healthy men.
Assessment of citrate concentrations in citrus fruit-based juices and beverages: implications for management of hypocitraturic nephrolithiasis. Effect of orange juice consumption on urinary stone risk factors. Longterm lemonade based dietary manipulation in patients with hypocitraturic nephrolithiasis.
Comparison between lemonade and potassium citrate and impact on urine pH and hour urine parameters in patients with kidney stone formation. Heilberg IP. Update on dietary recommendations and medical treatment of renal stone disease. Nephrol Dial Transpl ; Kidney stone disease review.
Pharmacotherapy of kidney stones. Expert Opin Pharmacother ; Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane Database of Systematic Reviews , Issue 1. N CD DOI: 0. Randomized prospective study of a nonthiazide diuretic, indapamide, in preventing calcium stone recurrences.
J Cardiovasc Pharmacol ; 22 suppl 6 :SS Thiazide diuretics and the risk for hip fracture. Appel LJ. Adverse metabolic side effects of thiazides: Implications for patients with calcium nephrolithiasis. Goldfarb DS. Prospects for dietary therapy of recurrent nephrolithiasis. Adv Chronic Kidney Dis ; Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. Effect of amiloride with or without hydrochlorothiazide on urinary calcium and saturation of calcium salts.
Long-term treatment of calcium nephrolithiasis with potassium citrate. Long-term treatment of renal lithiasis with potassium citrate.
Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol ; 4. Potassiummagnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. Effect of alkaline citrate therapy on clearance of residual renal stone fragments after extracorporeal shock wave lithotripsy in sterile calcium and infection nephrolithiasis patients.
Effect of potassium citrate therapy on stone recurrence and residual fragments after shockwave lithotripsy in lower caliceal calcium oxalate urolithiasis: A randomized controlled trial. Siener R, Hesse A. The effect of a vegetarian and different omnivorous diets on urinary risk factors for uric acid stone formation. Eur J Nutr ; Simple method for monitoring hour urinary urea nitrogen excretion.
J Lab Clin Med ; Correction of allopurinol dosing should be based on clearance of creatinine, but not plasma creatinine levels: another insight to allopurinol-related toxicity. J Clin Rheumatol ; Drugs ; Treatment of cystinuria. Effect of low sodium diet on urinary elimination of cystine in cystinuric children. Nephron ; A comparison of the effects of potassium citrate and sodium bicarbonate in the alkalinization of urine in homozygous cystinuria.
Urinary cystine excretion and capacity in patients with cystinuria. Management of cystine nephrolithiasis with alpha- mercaptopropionylglycine. Medical and surgical therapy of the cystine stone patient. Medical treatment of cystinuria: results of contemporary clinical practice. Captopril reduces urinary cystine excretion in cystinuria. Medical treatment of cystinuria: critical reappraisal of long-term results. Durability of the medical management of cystinuria.
Retrograde renoscopic fragmentation of moderate-size 1. Cystine: helical computerized tomography characterization of rough and smooth calculi in vitro. Cerrar sugerencias Buscar Buscar. Saltar el carrusel. Carrusel anterior. Carrusel siguiente. Explora Audiolibros. Explora Revistas. Explora Podcasts Todos los podcasts. Dificultad Principiante Intermedio Avanzado.
Explora Documentos. Documentos Bienestar Nefrolitiasis. Cargado por cateterdoblejota. Compartir este documento Compartir o incrustar documentos Opciones para compartir Compartir en Facebook, abre una nueva ventana Facebook. Denunciar este documento. Marcar por contenido inapropiado. Descargar ahora. Guardar Guardar Nefrolitiasis. Carrusel anterior Carrusel siguiente. Buscar dentro del documento. Osteol 7 3 : , El rol de la herencia es claro en algunas enfermedades como cistinuria o hiperoxalurias primarias, pero la litiasis idioptica tambin tiene una tendencia familiar, si bien los genes involucrados an no se conocen.
Fisiopatologa de la hipocitraturia Propiedades del citrato Actividad inhibitoria del citrato Manejo renal del citrato Metabolismo del citrato en el rin Causas de hipocitraturia en pacientes nefrolitisicos Litiasis rica Clculos infrecuentes de purinas Clculos de cido rico y amonio Fisiopatologa de la hiperuricosuria Litiasis cistnica Clnica de la urolitiasis Manejo en la urgencia Criterios de internacin Indicaciones al alta Evaluacin del paciente con clculos renales Prevencin de las recurrencias Tratamiento mdico de la urolitiasis Tratamiento de la hipercalciuria Tratamiento de la hipocitraturia Tratamiento de la litiasis rica Tratamiento de la cistinuria La formacin de piedras en el tracto urinario de adultos es un problema mdico-urolgico cada vez ms frecuente en pases industrializados, y tiene un alto impacto en los costos del sistema de salud.
Otra teora supone que la formacin de litos se inicia en el intersticio medular; luego las concreciones son extruidas hacia la papi- la, formando la clsica placa de Randall.
Adems, la deficiencia de una enzima, la kalicrena, podra causar hipercalciuria por defecto en la reabsorcin tubular: la kalicrena tisular activa el receptor de bradikinina tipo 2 B2R , y lleva a la activacin de la PKC y a la fosforilacin del TRPV5, el que se estabiliza, facilitando la entrada de calcio a las clulas tubulares.
Aumento de calcitriol, cambios en la secrecin de PTH Aumento del receptor de vitamina D nmero, sensibilidad Polimorfismos del receptor-sensor de calcio Deficiencia de la protena klotho Deficiencia de la enzima kalicrena tisular Formas sutiles de acidosis tubular Fisiopatologa de la hiperoxaluria El riesgo de formacin de piedras de oxalato de calcio aumenta con la mayor excrecin urinaria de oxalato.
El transporte de la especie menos abundante citrato-2 es la principal razn de la fuerte dependencia del pH en el transporte del citrato. El citrato ingresa a la clula del tbulo proximal no solamente por la membrana apical sino tambin por remocin a nivel del peritbulo, y Actualizaciones en Osteologa, VOL.
Los cambios en la homeostasis cido-base son los principales determinantes en la excrecin de citrato, porque afectan tanto su transporte luminal como su metabolizacin intracelular. El trmino ditesis gotosa se ha utilizado para describir a los pacientes que forman clculos de cido rico y presentan pH urinario bajo y excrecin fraccional de cido rico disminui- da similar a lo observado en pacientes con gota primaria pero que no presentan artritis gotosa. No obstante, en pacientes con litos de cido rico, hiperuricemia e hiperuricosuria, deben considerarse los sndromes hereditarios de sobreproduccin de cido rico, como la deficiencia de hipoxanti- na-guanina fosforribosiltransferasa HGPRT; OMIM A altas concentraciones el urato monosdico precipita y se hipotetiza Actualizaciones en Osteologa, VOL.
La identificacin del transportador de cido rico URAT1 constituye un avance en el entendimiento del manejo de los uratos por parte del rin. Figura 3. Transporte normal de cistina y aminocidos dibsicos en el tbulo proximal. En Wollaston observ unos clculos diferentes a los usuales, compuestos por placas hexagonales y solubles en lcali, y supuso que estaban constituidos por un compuesto que l denomin xido cstico.
Tabla 4.
0コメント